Exerpts from the publication

In an exploratory double-blind, placebo-controlled, cross-over study, adults with migraine received oral placebo and psilocybin (0.143 mg/kg) in 2 test sessions spaced 2 weeks apart. Subjects maintained headache diaries starting 2 weeks before the first session until 2 weeks after the second session. Physiological and psychological drug effects were monitored during sessions and several follow-up contacts with subjects were carried out to assure safety of study procedures.

Ten subjects were included in the final analysis. Over the 2-week period measured after single administration, the reduction in weekly migraine days from baseline was significantly greater after psilocybin (mean, − 1.65 (95% CI: − 2.53 to − 0.77) days/week) than after placebo (− 0.15 (− 1.13 to 0.83) days/week; p = 0.003, t(9) = 4.11). Changes in migraine frequency in the 2 weeks after psilocybin were not correlated with the intensity of acute psychotropic effects during drug administration.

The separation of acute psychotropic effects and lasting therapeutic effects is an important finding, urging further investigation into the mechanism underlying the clinical effects of select 5-HT2A receptor compounds in migraine, as well as other neuropsychiatric conditions.

Read more

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials

Michael C Mithoefer, Allison A Feduccia, Lisa Jerome, Anne Mithoefer, Mark Wagner, Zach Walsh, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin
May 2019

The potential synergistic effects between psychedelic administration and nature contact for the improvement of mental health

Sam Gandy, Matthias Forstmann, Robin Lester Carhart-Harris, Christopher Timmermann, David Luke, Rosalind Watts
December 2020

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

Davis, A,K., Barrett, F.S., Darrick G. May, D.G., Cosimano, M.P., Sepeda, N.D., Johnson, M.W., Finan, P.H., & Griffiths, R.R.
November 2020

People of color in North America report improvements in racial trauma and mental health symptoms following psychedelic experiences

Monnica T. Williams,Alan K. Davis,Yitong Xin,Nathan D. Sepeda,Pamela Colón Grigas,Sinead Sinnott & Angela M. Haeny
Dec 2020 10

Details