This review included two Cochrane reviews, 14 meta-analyses and 15 trials. Ketamine was studied versus placebo, versus other comparators and as an anesthetic adjuvant before electroconvulsive therapy. In 14 publications, ketamine provided a rapid antidepressant effect with a maximum efficacy reached at 24 hrs. Its effect lasted for 1-2 weeks after infusion, but a longer-term effect is little reported. Ketamine does not seem to improve depressive symptoms at the end of electroconvulsive sessions. Safety and tolerability profiles with ketamine at low single dose are generally good in depressed patients.
Strategies to Prolong Ketamine’s Efficacy in Adults with Treatment-Resistant Depression
Eric P McMullen, Yena Lee, Orly Lipsitz, Leanna M W Lui, Maj Vinberg, Roger Ho, Nelson B Rodrigues, Joshua D Rosenblat, Bing Cao, Hartej Gill, Kayla M Teopiz, Danielle S Cha, Roger S McIntyre