Psychedelic Medicine


Psychedelic Medicine


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Ketamine was initially developed as an anesthetic, and is still used as such, especially in children and in the field by military medics.  For years, IV Ketamine clinics have been treating depression and addiction across the country. Recently, the FDA approved a version of ketamine, called esketamine, as a nasal spray called Spravato, a therapy for treatment-resistant depression. 

Ketamine’s success rate is nearly double that of traditional antidepressant medications. At lower doses it can feel euphoric, and at higher doses, patients can experience hallucinations and even experience dissolving of the physical environment and body, in what is often referred to as a “K-hole” phenomenon.

In the United States, the Drug Enforcement Agency has Ketamine listed as Schedule III, meaning it requires a prescription to obtain. 


Antianhedonic Effect of Repeated Ketamine Infusions in Patients With Treatment Resistant Depression

Wilkowska A, Wiglusz MS, Gałuszko-Wegielnik M, Włodarczyk A, Cubała WJ.
October 2021

Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review

Johanna Louise Keeler, Janet Treasure, Mario F. Juruena, Carol Kan, Hubertus Himmerich
November 2021

Efficacy and safety of esketamine nasal spray by sex in patients with treatment-resistant depression: findings from short-term randomized, controlled trials

Robyn R. Jones, Marlene P. Freeman, Susan G. Kornstein, Kimberly Cooper, Ella J. Daly, Carla M. Canuso & Susan Nicholson
January 2022

Systematic review and meta-analysis of randomized controlled trials of ketamine in the treatment of refractory anxiety spectrum disorders

Elizabeth Whittaker, Alisher R. Dadabayev, Sonalee A. Joshi, and Paul Glue
December 2021


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