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Ketamine was initially developed as an anesthetic, and is still used as such, especially in children and in the field by military medics. For years, IV Ketamine clinics have been treating depression and addiction across the country. Recently, the FDA approved a version of ketamine, called esketamine, as a nasal spray called Spravato, a therapy for treatment-resistant depression.
Ketamine’s success rate is nearly double that of traditional antidepressant medications. At lower doses it can feel euphoric, and at higher doses, patients can experience hallucinations and even experience dissolving of the physical environment and body, in what is often referred to as a “K-hole” phenomenon.
In the United States, the Drug Enforcement Agency has Ketamine listed as Schedule III, meaning it requires a prescription to obtain.